Controlling Autoreactivity of CD4 T Cells by Local Tolerance Induction

Controlling Autoreactivity of CD4 T Cells by Local Tolerance Induction

Induction of T Regulatory Subsets from Naïve CD4+ T Cells after Exposure to Breast Cancer Adipose Derived Stem Cells

Background: Adipose derived stem cells (ASCs) provoke the accumulation and expansion of regulatory T cells, leading to the modulation of immune responses in tumor microenvironment. Objective: To assess the effect of tumoral ASCs on the trend of regulatory T cells differentiation. Methods: Peripheral blood naïve CD4+ T cells were co-cultured with ASCs derived from breast cancer or normal breast ...

Semimature Dendritic Cells Tolerance and CD8 T Cell Immunity by Simultaneous Induction of CD4 T Cell

Simultaneous induction of CD4 T cell tolerance and CD8 T cell immunity by semimature dendritic cells.

Previous studies suggested that depending on their maturation state, dendritic cells (DC) could either induce T cell tolerance (immature and semimature DC) or T cell activation (mature DC). Pretreatment of C57BL/6 mice with encephalitogenic myelin oligodendrocyte glycoprotein (MOG)(35-55) peptide-loaded semimature DC protected from MOG-induced autoimmune encephalomyelitis. This protection was m...

Induction of antigen-specific immune tolerance by TGF-beta-induced CD4+Foxp3+ regulatory T cells.

Like natural CD4(+)CD25(+) Treg cells, TGF-beta-induced Treg cells also prevent allograft rejection in MHC-mismatched organ transplantation models. In analyzing this effect with greater detail, we determined that injection of TGF-beta-induced, alloactivated CD4(+)CD25(+) cells induces antigen-specific immune tolerance in vivo. Increased CD4(+)CD25(+) cells in recipients contribute to this immun...